Recent output
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King’s College London
Studying RNA-binding proteins in human models of brain disease
White Lab explores how changes in RNA-binding proteins disrupt the health and function of human brain cells. Using stem-cell-derived neurons, organoids and transcriptomic approaches, we study early disease processes in neurodegeneration and related disorders of the nervous system.
White Lab
A growing research group focused on RNA biology, neurodegeneration, human stem-cell models and transcriptomics.
Research focus
RNA-binding proteins in human models of brain disease
We study RNA biology, neurodegeneration, stem-cell models and transcriptomic change.
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Mechanism
RNA-binding proteins
We study how proteins such as TDP-43 and related RNA regulators shape gene expression, splicing and cellular vulnerability in the nervous system.
Read moreModels
Human stem-cell systems
Our work uses human neurons, organoids and assembloids to investigate disease-relevant biology in experimentally tractable human models.
Explore modelsDiscovery
Transcriptomics and RNA analysis
We combine molecular and computational approaches to map gene expression, splicing, isoform change and early disease-associated signatures.
See our approachWelcome to White Lab
White Lab is an independent research group based at King’s College London. We are interested in a simple but important question: what happens when the systems that control RNA in our cells begin to go wrong?
RNA-binding proteins help cells decide how genetic information is processed and used. When these systems are disrupted, the effects can be especially damaging in the brain. Our work focuses on understanding these early changes in human cell and tissue models, with the aim of revealing why some cells become vulnerable in disease and how those changes might one day be targeted more effectively.
What we study
RNA-binding proteins and brain disease
We study proteins that help control RNA inside cells, including proteins linked to motor neurone disease, frontotemporal dementia and other neurological disorders.
Human models of the nervous system
Our work uses human stem-cell-based models, including neurons, organoids and assembloids, to study disease in systems that are both biologically relevant and experimentally useful.
Gene expression, splicing and RNA biology
We use transcriptomic approaches to understand how disrupted RNA regulation changes the way genes are used in cells, including changes in expression, splicing and isoform usage.
Early mechanisms and therapeutic discovery
By identifying the molecular changes that appear early, we hope to highlight pathways that matter most and support more informed strategies for therapeutic discovery.
How we work
Our research brings together human iPSC-derived neurons, brain organoids and assembloids, molecular neuroscience, transcriptomics, RNA analysis, and single-cell and long-read sequencing.
We are interested not only in strong science, but in communicating it clearly and openly to the communities who help make it possible, including collaborators, funders, charities, patients, families and the wider public.
- Human iPSC-derived neurons
- Forebrain organoids and assembloids
- Molecular and cellular neuroscience
- Transcriptomics and RNA analysis
- Single-cell and long-read sequencing
- Disease modelling and pathway discovery
Pipelines & Protocols
White Lab Neuro is committed to transparent and reproducible research. Our pipelines-and-protocols repository provides a central home for pipelines, workflows and version-controlled protocols developed in the lab.
As the lab grows, this repository will provide a clearer record of how analyses were run and how methods evolved across projects, supporting reproducibility, traceability and open science.
Latest from the lab
Follow research updates, publications, funding news and lab milestones as White Lab grows.
Visit the news pageFeatured research
Selected publications and research highlights will showcase the lab’s work in RNA-binding proteins, neurodegeneration and stem-cell-based disease modelling.
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White Lab Neuro is grateful for the support of charities, foundations, research partners and community organisations whose backing helps make our work possible.
Research made possible by
White Lab Neuro is grateful for the support of charities, foundations, research partners and community organisations whose backing helps make our work possible.
Connect with White Lab
We welcome enquiries from prospective students, collaborators, funders, charities and others interested in our work.
Whether you are interested in RNA biology, neurodegeneration, stem-cell models, transcriptomics or public engagement around neuroscience, we would be pleased to hear from you.
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